Complexity of cytokine network regulation of innate lymphoid cells in protective immunity

Cyril Seillet; Gabrielle T Belz; Lisa A Mielke

doi:10.1016/j.cyto.2014.06.002

Complexity of cytokine network regulation of innate lymphoid cells in protective immunity

Cytokine. 2014 Nov;70(1):1-10. doi: 10.1016/j.cyto.2014.06.002. Epub 2014 Jun 25.

Authors

Cyril Seillet¹, Gabrielle T Belz², Lisa A Mielke³

Affiliations

¹ Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address: [email protected].
² Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address: [email protected].
³ Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address: [email protected].

PMID: 24972988
DOI: 10.1016/j.cyto.2014.06.002

Abstract

The body's surface provides a critical barrier shielding us from various mechanical and pathogenic insults by virtue of the physical protection it provides and the presence of specialized populations of innate lymphoid cells (ILCs) that sense inflammatory signals induced by pathogens. This response plays a central role in the development and activation of early immune responses. While ILCs depend on common γ-chain cytokine signaling for their development, an essential component of the armory of these cells is their capacity to produce defensive cytokines when activated by viruses, microbes and other parasites. In this review, we describe the multiple intrinsic and extrinsic pathways that comprise the cytokine circuitry regulating the development and function of ILC necessary for protective immunity.

Keywords: Development; Homeostasis; Inflammation; Innate immunity; infection.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptive Immunity / immunology
Cytokines / immunology*
Cytokines / metabolism
Humans
Immunity, Innate / immunology*
Inflammation / immunology
Inflammation / metabolism
Lymphocytes / immunology*
Lymphocytes / metabolism
Models, Immunological
Signal Transduction / immunology*

Substances

Cytokines