1 1 Department of Medical Oncology, U.O. Oncologia Medica 2, IRCCS AOU San Martino-IST, Genova, Italy ; 2 Breast Data Centre and Medicine Department, Medical Oncology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium ; 3 Department of Medical Oncology, U.O. Sviluppo Terapie Innovative, IRCCS AOU San Martino-IST, Genova, Italy.