Development and validation of novel imaging technologies to assist translational studies in atherosclerosis

Robbert-Jan J H M Miserus; Sylvia Heeneman; Jos M A van Engelshoven; Marianne Eline Kooi; Mat J A P Daemen

doi:10.1016/j.ddtec.2006.06.008

Development and validation of novel imaging technologies to assist translational studies in atherosclerosis

Drug Discov Today Technol. 2006 Summer;3(2):195-204. doi: 10.1016/j.ddtec.2006.06.008.

Authors

Robbert-Jan J H M Miserus¹, Sylvia Heeneman², Jos M A van Engelshoven¹, Marianne Eline Kooi¹, Mat J A P Daemen³

Affiliations

¹ University of Maastricht, Department of Radiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.
² University of Maastricht, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:[email protected].
³ University of Maastricht, Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), P.O. Box 616, 6200 MD Maastricht, The Netherlands.

PMID: 24980408
DOI: 10.1016/j.ddtec.2006.06.008

Abstract

In the past decade, significant progress has been made to visualize atherosclerotic disease. Until recently, imaging technologies mainly focused on lumen and vessel wall visualization. Current advances and knowledge on the molecular mechanisms of initiation and progression of atherosclerosis has emphasized the need for imaging technologies and probes that can image function and biology rather than anatomy. This field of molecular imaging is now in rapid development with new imaging agents that aim at visualizing processes involved in atherosclerosis such as inflammation, macrophage activation, protease activity, angiogenesis, apoptosis, lipid accumulation and thrombus formation.: