Abstract
Group A streptococcal pyrogenic exotoxins A, B, and C (also known as scarlet fever toxins and erythrogenic toxins) were evaluated for relatedness to another streptococcus-derived lymphocyte mitogen, blastogen A. Streptococcal pyrogenic exotoxin A and blastogen A were immunologically cross-reactive and shared the same molecular weight, N-terminal amino acid sequence, and capacity to stimulate rabbit splenocyte proliferation nonspecifically.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Proteins / analysis*
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Electrophoresis, Polyacrylamide Gel
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Exotoxins / analysis*
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Immunoblotting
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Immunodiffusion
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Membrane Proteins*
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Mitogens / analysis*
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Pyrogens / analysis*
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Streptococcal Infections / immunology
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Streptococcus pyogenes / immunology*
Substances
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Bacterial Proteins
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Exotoxins
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Membrane Proteins
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Mitogens
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Pyrogens
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SpeA protein, Streptococcus pyogenes
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erythrogenic toxin
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streptococcal group A mitogen