Abstract
Three new lumazine peptides, penilumamides B-D (2-4), and one known analogue, penilumamide (1), together with a new cyclic pentapeptide, asperpeptide A (5), were isolated from the gorgonian-derived fungus Aspergillus sp. XS-20090B15. Among them, 2 was obtained from the feeding culture with l-methionine of this strain. All structures were elucidated by spectroscopic methods and chemical derivatization. Compounds 1-4 are rare lumazine peptides, of which 1 and 3 are formed from 2 by oxidation of the l-methionine residue.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkaloids / pharmacology
-
Animals
-
Anthozoa / microbiology*
-
Aspergillus / chemistry*
-
Bacillus cereus / drug effects
-
Escherichia coli / drug effects
-
Methionine / analogs & derivatives
-
Methionine / chemistry
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Nocardia / drug effects
-
Nuclear Magnetic Resonance, Biomolecular
-
Oligopeptides / chemistry
-
Peptides, Cyclic / chemistry
-
Peptides, Cyclic / isolation & purification*
-
Pseudomonas / drug effects
-
Pteridines / chemistry
-
Salmonella enterica / drug effects
-
Sesquiterpenes / pharmacology
-
Staphylococcus / drug effects
-
Vibrio / drug effects
Substances
-
Alkaloids
-
Oligopeptides
-
Peptides, Cyclic
-
Pteridines
-
Sesquiterpenes
-
asperpeptide A
-
penilumamide
-
penilumamide B
-
penilumamide C
-
penilumamide D
-
huperzine A
-
lumazine
-
Methionine