In vitro synergism observed with azithromycin, clarithromycin, minocycline, or tigecycline in association with antifungal agents against Pythium insidiosum

Antimicrob Agents Chemother. 2014 Sep;58(9):5621-5. doi: 10.1128/AAC.02349-14. Epub 2014 Jul 7.

Abstract

We describe here the in vitro activities of azithromycin, clarithromycin, minocycline, or tigecycline alone and in combination with amphotericin B, itraconazole, terbinafine, voriconazole, anidulafungin, caspofungin, or micafungin against 30 isolates of the oomycete Pythium insidiosum. The assays were based on the CLSI M38-A2 technique and the checkerboard microdilution method. The main synergisms observed were through the combination of minocycline with amphotericin B (73.33%), itraconazole (70%), and micafungin (70%) and of clarithromycin with micafungin (73.33%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology
  • Azithromycin / pharmacology*
  • Clarithromycin / pharmacology*
  • Drug Combinations
  • Drug Synergism
  • Humans
  • In Vitro Techniques
  • Microbial Sensitivity Tests
  • Minocycline / analogs & derivatives*
  • Minocycline / pharmacology*
  • Pythiosis / drug therapy
  • Pythium / drug effects*
  • Pythium / isolation & purification
  • Tigecycline

Substances

  • Antifungal Agents
  • Drug Combinations
  • Tigecycline
  • Azithromycin
  • Minocycline
  • Clarithromycin