Immunization-induced Anaplasma marginale-specific T-lymphocyte responses impaired by A. marginale infection are restored after eliminating infection with tetracycline

Clin Vaccine Immunol. 2014 Sep;21(9):1369-75. doi: 10.1128/CVI.00246-14. Epub 2014 Jul 9.

Abstract

Infection of cattle with Anaplasma marginale fails to prime sustained effector/memory T-cell responses, and high bacterial load may induce antigen-specific CD4 T exhaustion and deletion. We tested the hypothesis that clearance of persistent infection restores the exhausted T-cell response. We show that infection-induced T-cell exhaustion, characterized as loss of antigen-specific proliferation, and gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) production are partially restored in cattle following clearance of persistent infection with tetracycline.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anaplasma marginale / immunology*
  • Anaplasmosis / drug therapy
  • Anaplasmosis / immunology*
  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Cattle
  • Cattle Diseases / drug therapy
  • Cattle Diseases / immunology*
  • Cell Proliferation
  • Immunization
  • Interferon-gamma / metabolism
  • T-Lymphocytes / immunology*
  • Tetracycline / therapeutic use*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Anti-Bacterial Agents
  • Tumor Necrosis Factor-alpha
  • Interferon-gamma
  • Tetracycline