Application of endovascular coiling and subsequent Onyx 34 embolization in anterior communicating artery aneurysms with adjacent hematoma

Clin Neurol Neurosurg. 2014 Aug:123:40-4. doi: 10.1016/j.clineuro.2014.05.007. Epub 2014 May 14.

Abstract

Objective: Small anterior communicating artery aneurysms with recurrent bleeding and adjacent hematoma may have a high risk of post-operative rebleeding. This clinical study summarizes our preliminary experience with this subset of aneurysms, which were treated with endovascular coiling and subsequent Onyx 34 embolization.

Methods: We retrospectively reviewed the data of 9 patients suffering from small anterior communicating artery aneurysms treated with the combination of coils and Onyx. The clinical characteristics, angiographic outcomes, and follow-up results are reviewed.

Results: Endovascular coiling and Onyx embolization were successfully accomplished in all 9 cases. The Raymond scale ratings of the treatments are all class I with the parent arteries kept patent. One patient died of severe brain edema on the 5th post-operative day. The modified Rankin scale (mRS) score for the other 8 patients at follow-ups (6m to 26m, 15.8m on average) was 0 in 5 cases, 1 in 2 cases, and 3 in 1 case. Seven of 8 patients (87.5%) underwent angiographic follow-up that demonstrated persistent durable occlusion with no recanalization.

Conclusions: Endovascular coiling and subsequent Onyx 34 embolization may be effective in treating anterior communicating artery aneurysms with adjacent hematoma. Further studies with larger sample size and adequate follow-up are required to verify its safety and efficacy as well as to evaluate the long-term outcome.

Keywords: Anterior communicating artery aneurysm; Endovascular treatment; Onyx; Pseudoaneurysm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aneurysm, Ruptured / complications
  • Aneurysm, Ruptured / surgery*
  • Dimethyl Sulfoxide / therapeutic use*
  • Embolization, Therapeutic* / methods
  • Endovascular Procedures*
  • Female
  • Follow-Up Studies
  • Hematoma / complications
  • Hematoma / surgery*
  • Humans
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / diagnosis
  • Intracranial Aneurysm / surgery*
  • Male
  • Middle Aged
  • Polyvinyls / therapeutic use*
  • Retrospective Studies
  • Tantalum / therapeutic use*
  • Treatment Outcome

Substances

  • Onyx 34
  • Polyvinyls
  • Tantalum
  • Dimethyl Sulfoxide