Abstract
On the basis of terminal group electrostatic interactions (TGEI), a supra-amphiphile is formed between a homopolymer of polylactic acid with carboxyl group at one end (PLA-COOH) and hepta-6-hydrazyl-β-cyclodextrin (HH-CD). The amphiphile can self-assemble into a micellar structure in aqueous solution. The outer surface of the micelle, which is composed of cyclodextrins, can be further modified via host-guest interactions. Considering the biocompatibility of the building blocks, the application of the micelles in a nanocarrier of anticancer drugs is further explored.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Biological Transport
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Cell Survival / drug effects
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Doxorubicin / chemistry
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Doxorubicin / pharmacology
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Drug Carriers / chemistry*
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Drug Carriers / metabolism
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Drug Compounding
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Drug Liberation
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HeLa Cells
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Humans
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Lactic Acid / chemistry*
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Micelles
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Molecular Structure
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Polyesters
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Polymers / chemistry*
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Solutions
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Static Electricity
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Surface Properties
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Surface-Active Agents / chemistry*
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Water
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beta-Cyclodextrins / chemistry*
Substances
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Antineoplastic Agents
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Drug Carriers
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Micelles
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Polyesters
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Polymers
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Solutions
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Surface-Active Agents
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beta-Cyclodextrins
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Water
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Lactic Acid
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poly(lactide)
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Doxorubicin