Abstract
PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that phosphorylation is somehow required.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Base Sequence
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Binding Sites
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DNA / metabolism
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DNA-Binding Proteins / genetics*
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Gene Expression Regulation
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Humans
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Oncogene Proteins, Viral / genetics
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Oncogene Proteins, Viral / metabolism
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Oncogenes*
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-jun
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Transcription Factors / genetics*
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Transcription, Genetic
Substances
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DNA-Binding Proteins
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Oncogene Proteins, Viral
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-jun
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Transcription Factors
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Adenosine Triphosphate
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DNA