[Circulating tumor cells: cornerstone of personalized medicine]

J Gynecol Obstet Biol Reprod (Paris). 2014 Nov;43(9):640-8. doi: 10.1016/j.jgyn.2014.06.009. Epub 2014 Jul 10.
[Article in French]

Abstract

Cancer treatment has evolved toward personalized medicine. It is mandatory for clinicians to ascertain tumor biological features in order to optimize patients' treatment. Identification and characterization of circulating tumor cells demonstrated a prognostic value in many solid tumors. Here, we describe the main technologies for identification and characterization of circulating tumor cells and their clinical application in gynecologic and breast cancers.

Keywords: Biopsie liquide; Cellules tumorales circulantes; Circulating tumor cells; Liquid biopsy; Personalized medicine; Personnalisation traitement.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Biomarkers, Tumor / blood
  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / pathology
  • Breast Neoplasms* / therapy
  • Female
  • Genital Neoplasms, Female* / genetics
  • Genital Neoplasms, Female* / pathology
  • Genital Neoplasms, Female* / therapy
  • Humans
  • Immunohistochemistry
  • Neoplasm Metastasis / pathology
  • Neoplastic Cells, Circulating* / pathology
  • Precision Medicine*
  • Prognosis
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • Biomarkers, Tumor