NCOA5, a molecular link between type 2 diabetes and liver cancer

Connie Y Liu; Gen-Sheng Feng

doi:10.3978/j.issn.2304-3881.2014.04.02

NCOA5, a molecular link between type 2 diabetes and liver cancer

Hepatobiliary Surg Nutr. 2014 Jun;3(3):106-8. doi: 10.3978/j.issn.2304-3881.2014.04.02.

Authors

Connie Y Liu¹, Gen-Sheng Feng¹

Affiliation

¹ Biomedical Sciences Graduate Program, Department of Pathology, and Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093-0864, USA.

PMID: 25019069
PMCID: PMC4073315
DOI: 10.3978/j.issn.2304-3881.2014.04.02

Abstract

It is reported that nuclear receptor co-activator 5 (NCOA5) is a possible susceptibility gene to both type 2 diabetes (T2D) and hepatocellular carcinoma (HCC). The link between these two diseases is an important area of study with the growing prevalence of T2D. Thus, discovery of a genetic link may have great impact on the field. The group used NCOA5 (+/-) mice to observe the effects of the gene's haploinsufficiency on the symptoms of T2D and HCC and claimed NCOA5's regulation of IL-6 in the pathogenesis of the diseases.

Keywords: Nuclear receptor co-activator 5 (NCOA5); hepatocarcinoma; type 2 dibetes (T2D).

Grants and funding

R01 CA176012/CA/NCI NIH HHS/United States