Phantoms for diffuse optical imaging based on totally absorbing objects, part 2: experimental implementation

J Biomed Opt. 2014;19(7):076011. doi: 10.1117/1.JBO.19.7.076011.

Abstract

We present the experimental implementation and validation of a phantom for diffuse optical imaging based on totally absorbing objects for which, in the previous paper [J. Biomed. Opt.18(6), 066014, (2013)], we have provided the basic theory. Totally absorbing objects have been manufactured as black polyvinyl chloride (PVC) cylinders and the phantom is a water dilution of intralipid-20% as the diffusive medium and India ink as the absorber, filled into a black scattering cell made of PVC. By means of time-domain measurements and of Monte Carlo simulations, we have shown the reliability, the accuracy, and the robustness of such a phantom in mimicking typical absorbing perturbations of diffuse optical imaging. In particular, we show that such a phantom can be used to generate any absorption perturbation by changing the volume and position of the totally absorbing inclusion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Models, Biological
  • Monte Carlo Method
  • Optical Imaging / instrumentation*
  • Phantoms, Imaging*