Abstract
The cytotoxic T-cell and natural killer (NK)-cell lymphomas and related disorders are important but relatively rare lymphoid neoplasms that frequently are a challenge for practicing pathologists. This selective review, based on a meeting of the International Lymphoma Study Group, briefly reviews T-cell and NK-cell development and addresses questions related to the importance of precise cell lineage (αβ-type T cell, γδ T cell, or NK cell), the implications of Epstein-Barr virus infection, the significance of anatomic location including nodal disease, and the question of further categorization of enteropathy-associated T-cell lymphomas. Finally, developments subsequent to the 2008 World Health Organization Classification, including the recognition of indolent NK-cell and T-cell disorders of the gastrointestinal tract are presented.
MeSH terms
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics
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Biopsy
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Cell Lineage
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Diagnosis, Differential
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Enteropathy-Associated T-Cell Lymphoma / classification
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Enteropathy-Associated T-Cell Lymphoma / genetics
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Enteropathy-Associated T-Cell Lymphoma / immunology
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Enteropathy-Associated T-Cell Lymphoma / pathology
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Enteropathy-Associated T-Cell Lymphoma / virology
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Herpesvirus 4, Human / isolation & purification
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Humans
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Immunohistochemistry
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Killer Cells, Natural* / immunology
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Killer Cells, Natural* / pathology
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Killer Cells, Natural* / virology
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Lymphoma, T-Cell / classification*
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Lymphoma, T-Cell / genetics
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Lymphoma, T-Cell / immunology
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Lymphoma, T-Cell / pathology
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Lymphoma, T-Cell / virology
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Predictive Value of Tests
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Prognosis
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Receptors, Antigen, T-Cell / analysis
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Receptors, Antigen, T-Cell / genetics
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T-Lymphocytes, Cytotoxic* / immunology
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T-Lymphocytes, Cytotoxic* / pathology
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T-Lymphocytes, Cytotoxic* / virology
Substances
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Biomarkers, Tumor
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Receptors, Antigen, T-Cell