A rare case of an EML4-ALK-rearranged lung adenocarcinoma missed by in situ-hybridization but detected by RT-PCR

J Clin Pathol. 2014 Sep;67(9):839-40. doi: 10.1136/jclinpath-2014-202394.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adenocarcinoma / diagnostic imaging
  • Adenocarcinoma / enzymology
  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Adenocarcinoma of Lung
  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics*
  • Diagnostic Errors
  • Female
  • Gene Fusion
  • Gene Rearrangement*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence*
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / enzymology
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics*
  • Predictive Value of Tests
  • Reverse Transcriptase Polymerase Chain Reaction*
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor
  • EML4-ALK fusion protein, human
  • Oncogene Proteins, Fusion