Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

Marte W Gustavsen; Marte K Viken; Elisabeth G Celius; Tone Berge; Inger-Lise Mero; Pål Berg-Hansen; Jan H Aarseth; Kjell-Morten Myhr; Helle B Søndergaard; Finn Sellebjerg; Annette B Oturai; Jan Hillert; Lars Alfredsson; Tomas Olsson; Ingrid Kockum; Benedicte A Lie; Hanne F Harbo

doi:10.1016/j.jneuroim.2014.06.024

Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

J Neuroimmunol. 2014 Sep 15;274(1-2):174-9. doi: 10.1016/j.jneuroim.2014.06.024. Epub 2014 Jul 6.

Authors

Marte W Gustavsen¹, Marte K Viken², Elisabeth G Celius³, Tone Berge³, Inger-Lise Mero⁴, Pål Berg-Hansen⁵, Jan H Aarseth⁶, Kjell-Morten Myhr⁷, Helle B Søndergaard⁸, Finn Sellebjerg⁸, Annette B Oturai⁸, Jan Hillert⁹, Lars Alfredsson¹⁰, Tomas Olsson¹¹, Ingrid Kockum¹¹, Benedicte A Lie², Hanne F Harbo⁵

Affiliations

¹ Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: [email protected].
² Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway; Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, University of Oslo, Oslo, Norway.
³ Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway.
⁴ Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
⁵ Department of Neurology, Oslo University Hospital, Ullevål, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁶ The Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
⁷ The Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen Centre for MS-research, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
⁸ The Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
⁹ Department of Clinical Neuroscience, Karolinska Institutet, The Multiple Sclerosis Research Group, Center for Molecular Medicine, L8:00, Stockholm, Sweden.
¹⁰ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹¹ Department of Clinical Neuroscience, Karolinska Institutet, The Neuroimmunology Research Group, Stockholm, Sweden.

PMID: 25037176
DOI: 10.1016/j.jneuroim.2014.06.024

Abstract

Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.

Keywords: HLA; Killer cell immunoglobulin-like receptors; Multiple sclerosis; Oligoclonal bands.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
HLA-DRB1 Chains / genetics*
HLA-DRB1 Chains / immunology
Haplotypes
Histocompatibility Antigens Class I / genetics
Histocompatibility Antigens Class I / immunology
Histocompatibility Antigens Class II / genetics
Histocompatibility Antigens Class II / immunology
Humans
Killer Cells, Natural / immunology
Ligands
Male
Multiple Sclerosis, Relapsing-Remitting / genetics*
Multiple Sclerosis, Relapsing-Remitting / immunology
Oligoclonal Bands / genetics*
Oligoclonal Bands / immunology
Phenotype
Receptors, KIR2DL1 / genetics*
Receptors, KIR2DL1 / immunology
Receptors, KIR2DL2 / genetics*
Receptors, KIR2DL2 / immunology
Receptors, KIR2DL3 / genetics*
Receptors, KIR2DL3 / immunology
Registries

Substances

HLA-DRB1 Chains
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
KIR2DL1 protein, human
KIR2DL2 protein, human
KIR2DL3 protein, human
Ligands
Oligoclonal Bands
Receptors, KIR2DL1
Receptors, KIR2DL2
Receptors, KIR2DL3