Phragmalin-type limonoids with NF-κB inhibition from Chukrasia tabularis var. velutina

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3791-6. doi: 10.1016/j.bmcl.2014.06.069. Epub 2014 Jun 28.

Abstract

Chemical investigation on Chukrasia tabularis var. velutina led to the identification of eight new phragmalin-type limonoids (1-8), as well as 20 known analogues. Compounds 1-4 are a rare class of C-15-acyl phragmalin-type limonoids, and particularly compounds 2-4 also possess a δ-lactone ring formed between C-16 and C-30. All the isolates were evaluated for inhibitory effects on NF-κB production, and four of which showed significant inhibitions.

Keywords: Chukrasia tabularis var. velutina; NF-κB inhibition; Phragmalin-type limonoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dose-Response Relationship, Drug
  • HEK293 Cells
  • Humans
  • Limonins / chemistry
  • Limonins / isolation & purification
  • Limonins / pharmacology*
  • Meliaceae / chemistry*
  • Molecular Structure
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / metabolism
  • Structure-Activity Relationship

Substances

  • Limonins
  • NF-kappa B
  • phragmalin