GnRH agonist trigger and ovarian hyperstimulation syndrome: relook at 'freeze-all strategy'

Reprod Biomed Online. 2014 Sep;29(3):392-4. doi: 10.1016/j.rbmo.2014.05.012. Epub 2014 Jun 16.

Abstract

A case is reported of early onset ovarian hyperstimulation syndrome (OHSS) after gonadotrophin-releasing hormone agonist (GnRHa) trigger for final oocyte maturation in a GnRH antagonist protocol. The use of GnRHa in place of HCG as a trigger for final oocyte maturation in an antagonist IVF cycle has been proposed as a method for preventing OHSS in predicted high-responders. This approach, however, did not prevent the occurrence of OHSS in our case despite a freeze-all strategy. To the best of our knowledge, this is a possible index case of severe OHSS with GnRHa trigger for oocyte maturation without any luteal HCG rescue for a high responder, despite IVF cycle segmentation.

Keywords: AMH level; GnRH agonist; GnRH antagonist protocol; ovarian hyperstimulation syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cryopreservation
  • Female
  • Fertility Agents, Female / adverse effects*
  • Gonadotropin-Releasing Hormone / agonists*
  • Humans
  • Ovarian Hyperstimulation Syndrome / chemically induced*
  • Ovulation Induction / adverse effects*
  • Ovulation Induction / methods

Substances

  • Fertility Agents, Female
  • Gonadotropin-Releasing Hormone