Abstract
Following s.c. administration of purified protein A, to 7,12-dimethylbenz(alpha)anthracene-induced mammary-tumor-bearing rats, a regenerated metabolism of the carcinogen was observed. The antitumor effect of protein A was evident from the decrease in tumor volume. The phase I and phase II enzyme activities suggest that protein A has the ability to induce the mixed function oxidases activity, which are active in the metabolism of xenobiotics.
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene / toxicity
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Alkaline Phosphatase / blood
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Animals
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Biomarkers, Tumor / blood
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Cytochrome P-450 Enzyme System / metabolism
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Cytochrome b Group / metabolism
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Cytochromes b5
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Enzyme Induction
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Female
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Glutathione / metabolism
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Glutathione Transferase / metabolism
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Mammary Neoplasms, Experimental / enzymology*
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Mixed Function Oxygenases / biosynthesis*
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Rats
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Rats, Inbred Strains
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Reference Values
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Staphylococcal Protein A / pharmacology*
Substances
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Biomarkers, Tumor
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Cytochrome b Group
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Staphylococcal Protein A
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9,10-Dimethyl-1,2-benzanthracene
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Cytochromes b5
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Cytochrome P-450 Enzyme System
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Mixed Function Oxygenases
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Glutathione Transferase
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Alkaline Phosphatase
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Glutathione