Orbital schwannoma: a clinicopathologic study

Int Ophthalmol. 2015 Aug;35(4):481-6. doi: 10.1007/s10792-014-9973-1. Epub 2014 Jul 23.

Abstract

The aim of the study was to study the clinical, radiological and histopathological characteristics of orbital schwannomas. It is a retrospective study conducted at a tertiary eye care hospital. A review of histopathological records of the orbital tumors operated between 1993 and 2011 was done. The clinical, imaging and histopathological details of cases of orbital schwannoma were analyzed. Forty-nine cases of orbital schwannomas identified. The age ranged from 8 to 65 years with a female preponderance. The median duration of symptoms was 3 years. Computed tomography findings varied from a hypodense to hyperdense lesion with nil to marked contrast enhancement. USG demonstrated a defined lesion with variable internal reflectivity. Varied proportions of Antoni A and Antoni B areas were found on histopathology of the masses. Hypodense or cystic areas on imaging significantly correlated with Antoni B areas on histopathology. Orbital schwannoma is a rare tumor. The incidence of schwannoma in our institution is 6.5 %. Variable imaging features were found. The definite diagnosis can be established on the basis of histopathological and immunohistochemical studies.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Cysts / diagnostic imaging
  • Cysts / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neurilemmoma / diagnostic imaging
  • Neurilemmoma / pathology*
  • Orbital Neoplasms / diagnostic imaging
  • Orbital Neoplasms / pathology*
  • Retrospective Studies
  • Tomography, X-Ray Computed
  • Young Adult