Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach

Chem Commun (Camb). 2014 Sep 14;50(71):10218-21. doi: 10.1039/c4cc04852k.

Abstract

We discovered a novel organocatalysed multicomponent domino Knoevenagel-aza-Michael-cyclocondensation reaction leading to an unprecedented straightforward synthesis of 1,5-diazabicyclo[3.3.0]octane-2,6-diones. The specific capability of the (DHQ)2PHAL organocatalyst in this process was also highlighted to eventually furnish the corresponding bicyclopyrazolidinones with up to 96 : 4 er.