Infection with possible precursor of avian influenza A(H7N9) virus in a child, China, 2013

Emerg Infect Dis. 2014 Aug;20(8):1362-5. doi: 10.3201/eid2008.140325.

Abstract

During the early stage of the avian influenza A(H7N9) epidemic in China in March 2013, a strain of the virus was identified in a 4-year-old boy with mild influenza symptoms. Phylogenetic analysis indicated that this strain, which has similarity to avian subtype H9N2 viruses, may represent a precursor of more-evolved H7N9 subtypes co-circulating among humans.

Keywords: A(H7N9); China; adaption; avian influenza virus; evolution; fomite; genome sequence; pediatric; phylogenetics; respiratory infections; viruses; zoonoses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Child, Preschool
  • China / epidemiology
  • Genome, Viral
  • Genotype
  • Humans
  • Influenza A Virus, H7N9 Subtype / classification
  • Influenza A Virus, H7N9 Subtype / genetics*
  • Influenza A Virus, H7N9 Subtype / isolation & purification
  • Influenza, Human / epidemiology*
  • Influenza, Human / virology*
  • Male
  • Molecular Sequence Data
  • Neuraminidase / genetics
  • Phylogeny
  • Sequence Alignment
  • Viral Proteins / genetics

Substances

  • Viral Proteins
  • NA protein, influenza A virus
  • Neuraminidase