Effects of Lys-Glu-Trp peptide on cell-cell interactions and vascular endothelium proliferation under normal conditions and during atherosclerosis

V V Malinin; A O Durnova; V O Polyakova; I M Kvetnoi

doi:10.1007/s10517-014-2556-3

Effects of Lys-Glu-Trp peptide on cell-cell interactions and vascular endothelium proliferation under normal conditions and during atherosclerosis

Bull Exp Biol Med. 2014 Jul;157(3):324-6. doi: 10.1007/s10517-014-2556-3. Epub 2014 Jul 29.

Authors

V V Malinin¹, A O Durnova, V O Polyakova, I M Kvetnoi

Affiliation

¹ Tsitomed Biomedical Research-and-Production Complex, St. Petersburg, Russia.

PMID: 25065310
DOI: 10.1007/s10517-014-2556-3

Abstract

The molecular mechanism of atherosclerosis is based on decreased expression of signal molecules connexin (Cx37 and Cx40), vascular endothelial growth factor (VEGF), and proliferative protein Ki-67, which characterize the processes of cell-cell interactions and proliferation of vascular endotheliocytes. Lys-Glu-Trp peptide in doses of 4 and 40 μg/ml promoted recovery of Cx37, Cx40, and VEGF expression in cultured endotheliocytes from the aorta of patients with atherosclerosis, which attests to vasoprotective effects of this agent.

MeSH terms

Atherosclerosis / pathology*
Cell Communication / drug effects*
Cell Proliferation / drug effects*
Cells, Cultured
Connexins / metabolism
Endothelial Cells / drug effects
Endothelial Cells / physiology*
Endothelium, Vascular / pathology
Gap Junction alpha-4 Protein
Gap Junction alpha-5 Protein
Humans
Ki-67 Antigen / metabolism
Oligopeptides / pharmacology*
Vascular Endothelial Growth Factor A / metabolism

Substances

Connexins
Ki-67 Antigen
Oligopeptides
VEGFA protein, human
Vascular Endothelial Growth Factor A
lysyl-glutamyl-tryptophan