Abstract
Bone marrow-derived mesenchymal stem cells (BM-MSCs) in the marrow stroma provide a scaffold for hematopoiesis. Chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 have been shown to affect the engraftment of hematopoietic stem cells. However, little is known about SDF-1/CXCR4's functions in regulating BM-MSCs in humans. As an initial step toward this issue, we have evaluated expression of SDF-1/CXCR4 in the BM-MSCs from a cohort of adolescents and young adults with acute lymphoblastic leukemia (ALL). We found a decrease of the CXCR4 level and an increase of the SDF-1 level in these MSCs of ALL. Moreover, cell migration appeared to be impaired in the MSCs of ALL. These changes were reversed by chemotherapy. Taken together, alteration of SDF-1/CXCR4 expression could be potentially developed as biomarkers for monitoring the effectiveness of chemotherapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Bone Marrow Cells / drug effects
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Bone Marrow Cells / physiology
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Cell Differentiation / drug effects
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Cell Differentiation / physiology
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Cell Movement / drug effects
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Cell Movement / physiology
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Cells, Cultured
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Chemokine CXCL12 / genetics*
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Chemokine CXCL12 / metabolism
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Dipeptidyl Peptidase 4 / genetics
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Dipeptidyl Peptidase 4 / metabolism
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Drug Monitoring / methods*
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Gene Expression / drug effects
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Hematopoiesis / drug effects
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Hematopoiesis / physiology
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Humans
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Mesenchymal Stem Cells / drug effects*
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Mesenchymal Stem Cells / physiology
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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Receptors, CXCR4 / genetics*
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Receptors, CXCR4 / metabolism
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Young Adult
Substances
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CXCL12 protein, human
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CXCR4 protein, human
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Chemokine CXCL12
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Receptors, CXCR4
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DPP4 protein, human
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Dipeptidyl Peptidase 4