Primary Cutaneous Gamma-Delta T-Cell Lymphoproliferative Disorder in a 3-Year-Old Boy

Am J Dermatopathol. 2015 Jul;37(7):567-9. doi: 10.1097/DAD.0000000000000185.

Abstract

Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a rare disorder, constituting less than 1% of primary cutaneous lymphomas. Most cases occur in adults and may present as plaques or nodules with ulceration. Here we describe an unusual case of PCGD-TCL in a 3-year-old boy who presented with asymptomatic subcutaneous nodules. To our knowledge, this report represents one of the youngest reported patients with gamma-delta lymphoma/lymphoproliferative disorder. In addition, our patient has an indolent clinical presentation with greater than 1 year clinical follow-up. Because gamma-delta T-cell lymphomas are exceedingly rare in children, we acknowledge that the clinical course/outcome in young patients is still unclear. We hope to add to the recognition that PCGD-TCLs demonstrate a wide clinical spectrum of disease with relatively indolent presentations in some cases.

Publication types

  • Case Reports

MeSH terms

  • CD3 Complex / analysis*
  • Child, Preschool
  • Humans
  • Lymphoma, T-Cell, Cutaneous / chemistry*
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Male
  • Poly(A)-Binding Proteins / analysis
  • Rare Diseases / metabolism
  • Rare Diseases / pathology
  • Receptors, Antigen, T-Cell, gamma-delta / analysis*
  • Skin Neoplasms / chemistry*
  • Skin Neoplasms / pathology*
  • T-Cell Intracellular Antigen-1

Substances

  • CD3 Complex
  • Poly(A)-Binding Proteins
  • Receptors, Antigen, T-Cell, gamma-delta
  • T-Cell Intracellular Antigen-1
  • TIA1 protein, human