Abstract
Helicobacter (H.) suis is capable of infecting various animals including humans, and H. suis infections can lead to gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Recently, we reported that interferon-γ (IFN-γ) was highly expressed in the stomachs of H. suis-infected mice, but the direct relationship between the upregulation of IFN-γ expression and the formation of gastric lymphoid follicles after H. suis infection remains unclear. Here, we demonstrated that the IFN-γ produced by B cells plays an important role in the formation of gastric lymphoid follicles after H. suis infection. In addition, IFN-γ-producing B cells evoked gastric lymphoid follicle formation independent of T-cell help, suggesting that they are crucial for the development of gastric MALT induced by Helicobacter infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adoptive Transfer
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Animals
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B-Lymphocytes / immunology*
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B-Lymphocytes / metabolism*
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism
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Chemokine CXCL13 / genetics
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Chemokine CXCL13 / metabolism
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Dendritic Cells / immunology
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Dendritic Cells / metabolism
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Disease Models, Animal
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Female
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Gastric Mucosa / immunology
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Gastric Mucosa / metabolism*
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Gastric Mucosa / microbiology
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Gastric Mucosa / pathology
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Gastritis / immunology
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Gastritis / metabolism
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Gastritis / microbiology
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Gene Expression Regulation
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Helicobacter Infections / immunology*
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Helicobacter Infections / metabolism*
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Helicobacter Infections / microbiology
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Helicobacter heilmannii / immunology*
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Interferon-gamma / biosynthesis*
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Interferon-gamma / genetics
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Mice
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Mice, Knockout
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Stomach / immunology*
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Stomach / microbiology
Substances
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Chemokine CXCL13
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Interferon-gamma