[The PRRSV-serumneutralization test detects gaps in herd immunity]

Berl Munch Tierarztl Wochenschr. 2014 Jul-Aug;127(7-8):305-13.
[Article in German]

Abstract

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) appears in two genotypes (EU and US), for both genotypes attenuated live-vaccines are available. A cross-sectional study in 38 Bavarian sow herds was performed to assess the level of neutralizing antibodies. Per herd 38 blood samples were collected (10 weaned piglets, 10 gilts and 6 sows of 1./2., 3J4. and 5/6. parity, respectively). Sera were tested by ELISA, serumneutralization test (SNT) against EU- and US-vaccine virus, and pooled sera were tested by real-time RT-PCR. Herds were classified by the last vaccination of sows as "Vacc EU" "Vacc US"and "nv (non-vaccinated) and by detection of PRRSV-US and vaccination of piglets were not included as variables. Sows of group (2) Vacc EU/EU- showed the highest EU-SNT-titers irrespective of parity. Groups (5) Vacc US/EU+ and (1) Vacc EU/EU+ followed in descending order. Significantly lower SNT-titers in (1) Vacc EU/EU+ were especially observed in sows of 1/2. Parity (Kruskal-Wallis, p < 0.05). Very low SNT-titers were observed in the three remaining groups (3) nv/EU+, (4) nv/EU- and (6) Vacc US/EU-. In US-vaccinated herds detection of PRRSV-EU coincided with strong ELISA-reactivity in all animal groups. In EU-vaccinated herds this was only observed for weaned piglets. Sows showed a strong ELISA-reactivity irrespective of detection of PRRSV-EU. The value of the ELISA is restricted to the certification of PRRSV-free herds. The EU-SNT reflects the level of herd immunity at least against vaccine virus; it indicates gaps in herd immunity.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antibodies, Neutralizing / blood
  • Antibodies, Viral / blood*
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay / veterinary
  • European Union
  • Female
  • Genotype
  • Germany
  • Immunity, Herd*
  • Male
  • Neutralization Tests / veterinary*
  • Porcine Reproductive and Respiratory Syndrome / immunology*
  • Porcine Reproductive and Respiratory Syndrome / prevention & control
  • Porcine respiratory and reproductive syndrome virus / classification
  • Porcine respiratory and reproductive syndrome virus / genetics
  • Porcine respiratory and reproductive syndrome virus / immunology*
  • Swine
  • Vaccines, Attenuated / immunology
  • Viral Vaccines / immunology*

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Vaccines, Attenuated
  • Viral Vaccines