A growing role for Aurora A in chromosome instability

Ana R R Maia; Roy G H P van Heesbeen; René H Medema

doi:10.1038/ncb3018

A growing role for Aurora A in chromosome instability

Nat Cell Biol. 2014 Aug;16(8):739-41. doi: 10.1038/ncb3018.

Authors

Ana R R Maia¹, Roy G H P van Heesbeen¹, René H Medema¹

Affiliation

¹ Division of Cell Biology I and Cancer Genomics Center, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

PMID: 25082197
DOI: 10.1038/ncb3018

Abstract

Chromosome instability is a major hallmark of cancer, but its molecular causes are still poorly understood. A study now describes how genetic alterations frequently found in colorectal cancer increase microtubule assembly rates during mitosis and promote chromosome instability.

Publication types

Comment

MeSH terms

Aurora Kinase A / genetics*
Checkpoint Kinase 2 / genetics*
Chromosomal Instability*
Colorectal Neoplasms / genetics*
Humans
Microtubules / genetics*

Substances

Checkpoint Kinase 2
AURKA protein, human
Aurora Kinase A
CHEK2 protein, human