Abstract
We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Amygdala / physiology*
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Child
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DNA Methylation / physiology
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Epigenesis, Genetic / physiology*
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Female
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Genotype
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Humans
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Linear Models
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Magnetic Resonance Imaging*
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Male
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Models, Neurological*
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Predictive Value of Tests
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Promoter Regions, Genetic / physiology
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Serotonin Plasma Membrane Transport Proteins / genetics*
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Serotonin Plasma Membrane Transport Proteins / physiology*
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Young Adult
Substances
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins