Abstract
The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. In this review, to understand the regulatory mechanism(s) of NEDD4 as well as the signaling pathways controlled by NEDD4, we briefly describe the NEDD4 upstream regulators and its downstream ubiquitin substrates. Moreover, we further discuss its oncogenic roles in human malignancies. Therefore, targeting NEDD4 could be a potential therapeutic strategy for treatment of human cancers.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antineoplastic Agents / adverse effects
-
Antineoplastic Agents / therapeutic use*
-
Drug Design*
-
Endosomal Sorting Complexes Required for Transport / antagonists & inhibitors*
-
Endosomal Sorting Complexes Required for Transport / metabolism
-
Humans
-
Molecular Targeted Therapy*
-
Nedd4 Ubiquitin Protein Ligases
-
Neoplasms / drug therapy*
-
Neoplasms / enzymology
-
Neoplasms / pathology
-
Proteasome Endopeptidase Complex / metabolism*
-
Proteasome Inhibitors / adverse effects
-
Proteasome Inhibitors / therapeutic use*
-
Signal Transduction / drug effects
-
Ubiquitin-Protein Ligases / antagonists & inhibitors*
-
Ubiquitin-Protein Ligases / metabolism
-
Ubiquitination / drug effects
Substances
-
Antineoplastic Agents
-
Endosomal Sorting Complexes Required for Transport
-
Proteasome Inhibitors
-
Nedd4 Ubiquitin Protein Ligases
-
Nedd4 protein, human
-
Ubiquitin-Protein Ligases
-
Proteasome Endopeptidase Complex