Synthesis of functionalized β-lactams and pyrrolidine-2,5-diones through a metal-free sequential Ugi-4CR/cyclization reaction

Elmira Ghabraie; Saeed Balalaie; Saber Mehrparvar; Frank Rominger

doi:10.1021/jo5010422

Synthesis of functionalized β-lactams and pyrrolidine-2,5-diones through a metal-free sequential Ugi-4CR/cyclization reaction

J Org Chem. 2014 Sep 5;79(17):7926-34. doi: 10.1021/jo5010422. Epub 2014 Aug 18.

Authors

Elmira Ghabraie¹, Saeed Balalaie, Saber Mehrparvar, Frank Rominger

Affiliation

¹ Peptide Chemistry Research Center, K. N. Toosi University of Technology , P.O. Box 15875-4416, Tehran, Iran.

PMID: 25105212
DOI: 10.1021/jo5010422

Abstract

An efficient approach for the synthesis of functionalized β-lactams and pyrrolidine-2,5-diones was achieved through a sequential Ugi-4CR/cyclization reaction. Diversity-oriented synthesis, good to high yields, easy workup, and short reaction times are advantages of this procedure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques / methods
Cyclization
Metals / chemistry*
Pyrrolidinones / chemical synthesis*
Stereoisomerism
beta-Lactams / chemical synthesis*

Substances

Metals
Pyrrolidinones
beta-Lactams