Patient-specific flexible and stretchable devices for cardiac diagnostics and therapy

Sarah R Gutbrod; Matthew S Sulkin; John A Rogers; Igor R Efimov

doi:10.1016/j.pbiomolbio.2014.07.011

Patient-specific flexible and stretchable devices for cardiac diagnostics and therapy

Prog Biophys Mol Biol. 2014 Aug;115(2-3):244-51. doi: 10.1016/j.pbiomolbio.2014.07.011. Epub 2014 Aug 5.

Authors

Sarah R Gutbrod¹, Matthew S Sulkin¹, John A Rogers², Igor R Efimov³

Affiliations

¹ Biomedical Engineering, Washington University in St Louis, USA.
² Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, USA.
³ Biomedical Engineering, Washington University in St Louis, USA. Electronic address: [email protected].

Abstract

Advances in material science techniques and pioneering circuit designs have led to the development of electronic membranes that can form intimate contacts with biological tissues. In this review, we present the range of geometries, sensors, and actuators available for custom configurations of electronic membranes in cardiac applications. Additionally, we highlight the desirable mechanics achieved by such devices that allow the circuits and substrates to deform with the beating heart. These devices unlock opportunities to collect continuous data on the electrical, metabolic, and mechanical state of the heart as well as a platform on which to develop high definition therapeutics.

Keywords: Bioelectronics; Imaging; Physiology.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Biocompatible Materials / chemical synthesis
Body Surface Potential Mapping / instrumentation*
Defibrillators, Implantable*
Elastic Modulus
Electrocardiography / instrumentation*
Electrodes*
Equipment Design
Equipment Failure Analysis
Membranes, Artificial*
Pacemaker, Artificial*

Substances

Biocompatible Materials
Membranes, Artificial

Abstract

Publication types

MeSH terms

Substances

Grants and funding