Abstract
CoA (coenzyme A) is an essential cofactor that is involved in many metabolic processes. CoA is derived from pantothenate in five biosynthetic reactions. The CoA biosynthetic pathway is regulated by PanKs (pantothenate kinases) and four active isoforms are expressed in mammals. The critical physiological functions of the PanKs are revealed by systematic deletion of the Pank genes in mice.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Coenzyme A / metabolism
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Mice
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Mitochondria / microbiology
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Phosphotransferases (Alcohol Group Acceptor) / genetics
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Phosphotransferases (Alcohol Group Acceptor) / metabolism*
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
Substances
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Protein Isoforms
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Phosphotransferases (Alcohol Group Acceptor)
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pantothenate kinase
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Coenzyme A