Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities

Fitoterapia. 2014 Oct:98:254-9. doi: 10.1016/j.fitote.2014.08.004. Epub 2014 Aug 10.

Abstract

Five new lanostane triterpenoids, ganoderic acid XL1 (1), ganoderic acid XL2 (2), 20-hydroxy-ganoderic acid AM1 (3), ganoderenic acid AM1 (4) and ganoderesin C (5), together with five known triterpenoids (6-10) were isolated from the fruiting bodies of Ganoderma theaecolum. Chemical structures were elucidated on the basis of spectroscopic evidence, including 1D, 2D NMR, mass spectrometric data and circular dichroism spectra. Compounds 1, 4, 5, 8, 9 and 10 (10 μM) exhibited hepatoprotective activities against DL-galactosamine-induced cell damage in HL-7702 cells.

Keywords: Ganoderma; Ganoderma theaecolum; Hepatoprotective activity; Triterpenoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Fruiting Bodies, Fungal / chemistry
  • Galactosamine / adverse effects
  • Ganoderma / chemistry*
  • Hepatocytes / drug effects*
  • Humans
  • Molecular Structure
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification

Substances

  • Triterpenes
  • ganoderic acid
  • Galactosamine