Cystoprostatectomy versus prostatectomy alone for locally advanced or recurrent pelvic cancer

ANZ J Surg. 2016 Jan-Feb;86(1-2):54-8. doi: 10.1111/ans.12808. Epub 2014 Aug 12.

Abstract

Background: There is minimal published data evaluating the oncological outcome of rectal resection with prostatectomy alone versus rectal resection with cystoprostatectomy in patients undergoing pelvic exenteration for locally advanced or recurrent pelvic cancer. This study aims to evaluate the oncological and functional outcomes of performing rectal resection with prostatectomy alone compared with rectal resection with cystoprostatectomy in patients undergoing pelvic exenteration.

Methods: Consecutive patients undergoing pelvic exenteration for locally advanced or recurrent pelvic cancer between 1998 and 2012 were identified from a prospectively maintained database. Patients undergoing rectal resection with prostatectomy alone were compared with a control group who underwent rectal resection with cystoprostatectomy and urostomy formation. The primary outcome was overall survival. Secondary outcomes analysed in the prostatectomy group included completeness of resection, continence and erectile function.

Results: Eleven rectal resections with prostatectomy were compared with 20 rectal resections with cystoprostatectomy. R0 resection was achieved in 73 and 65% respectively. There was no difference in overall survival (P = 0.40). Urinary continence was achieved in 36% of prostatectomy alone patients, while 27% experienced mild incontinence. Erectile function was poor, with only one patient able to maintain normal erections.

Conclusion: In appropriately selected patients with invasive pelvic tumours, rectal resection with prostatectomy alone provides adequate oncological outcomes. The ability to achieve an R0 resection was not compromised and overall survival is comparable with cystoprostatectomy. Urinary function is reasonable in most patients, although sexual function is compromised in almost all.

Keywords: cystoprostatectomy; incontinence; multivisceral resection; pelvic exenteration; rectal cancer.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cystectomy / methods*
  • Cystectomy / statistics & numerical data
  • Erectile Dysfunction / epidemiology
  • Erectile Dysfunction / etiology
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / epidemiology
  • Neoplasm Recurrence, Local / surgery*
  • New Zealand / epidemiology
  • Pelvic Exenteration / methods
  • Pelvic Exenteration / statistics & numerical data
  • Pelvic Neoplasms / epidemiology
  • Pelvic Neoplasms / surgery*
  • Prostatectomy / methods*
  • Prostatectomy / statistics & numerical data
  • Rectal Neoplasms / epidemiology
  • Rectal Neoplasms / surgery*
  • Retrospective Studies
  • Treatment Outcome
  • Urinary Incontinence / epidemiology
  • Urinary Incontinence / etiology
  • Urologic Surgical Procedures / methods
  • Urologic Surgical Procedures / statistics & numerical data