This paper reviews neuroimaging studies of depressive disorders conducted in Chinese populations since 2000. Both cross-sectional and longitudinal studies using structural and functional imaging techniques have compared different types of depressed individuals, with and without specific genotypes, and the characteristics of depressed individuals before and after treatment with antidepressants. Many of the findings are unstable - probably because most of the studies are underpowered - but there have been some important contributions to the international literature. Future studies in China need to use standardized methods, longitudinal designs, and joint application of both structural and functional MRI.
本文回顾了自2000年以来在中国人群中有关抑郁症的神经影像学研究。利用结构成像和功能成像技术的横断面研究和纵向研究比较了不同类型的抑郁症患者、有无特定基因型的抑郁症患者、和抗抑郁药治疗前后抑郁症患者的特征。许多研究结果不稳定--可能是因为大部分的研究的检验效能较低--但对国际文献仍做出了重要的贡献。中国未来的研究需要使用标准化的方法、纵向设计、以及结构和功能性磁共振成像的联合应用。
Keywords: China; depressive disorder; functional imaging; neuroimaging; review; structural imaging.