Achieving 1% NMR polarization in water in less than 1min using SABRE

Haifeng Zeng; Jiadi Xu; Michael T McMahon; Joost A B Lohman; Peter C M van Zijl

doi:10.1016/j.jmr.2014.07.004

Achieving 1% NMR polarization in water in less than 1min using SABRE

J Magn Reson. 2014 Sep:246:119-21. doi: 10.1016/j.jmr.2014.07.004. Epub 2014 Jul 19.

Authors

Haifeng Zeng¹, Jiadi Xu², Michael T McMahon², Joost A B Lohman³, Peter C M van Zijl⁴

Affiliations

¹ Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA. Electronic address: [email protected].
² Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA.
³ Bruker UK Limited, Banner Lane, Coventry, UK.
⁴ Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, Maryland, USA. Electronic address: [email protected].

Abstract

The development of biocompatible hyperpolarized media is a crucial step towards application of hyperpolarization in vivo. This article describes the achievement of 1% hyperpolarization of 3-amino-1,2,4-triazine protons in water using the parahydrogen induced polarization technique based on signal amplification by reversible exchange (SABRE). Polarization was achieved in less than 1 min.

Keywords: Hyperpolarization; Parahydrogen; SABRE.

Grants and funding

P30 CA006973/CA/NCI NIH HHS/United States