A case of secondary syphilis demonstrating nephrotic syndrome and a solitary intrahepatic mass in a human immunodeficiency virus-1-infected patient

Hiroshi Koganemaru; Shigemi Hitomi; Hirayasu Kai; Kunihiro Yamagata

doi:10.1016/j.jiac.2014.07.013

A case of secondary syphilis demonstrating nephrotic syndrome and a solitary intrahepatic mass in a human immunodeficiency virus-1-infected patient

J Infect Chemother. 2015 Jan;21(1):62-4. doi: 10.1016/j.jiac.2014.07.013. Epub 2014 Aug 7.

Authors

Hiroshi Koganemaru¹, Shigemi Hitomi², Hirayasu Kai³, Kunihiro Yamagata³

Affiliations

¹ Department of Infectious Diseases, Faculty of Medicine, University of Tsukuba, Japan. Electronic address: [email protected].
² Department of Infectious Diseases, Faculty of Medicine, University of Tsukuba, Japan.
³ Department of Nephrology, Faculty of Medicine, University of Tsukuba, Japan.

PMID: 25127155
DOI: 10.1016/j.jiac.2014.07.013

Abstract

A 37-year-old, human immunodeficiency virus-1-infected Japanese man was referred because of nephrotic syndrome following emergence of generalized skin rash. Serological tests for syphilis turned out to be positive within ten months of the referral. Abdominal echography incidentally revealed a solitary intrahepatic mass without a detectable blood flow in segment 7. The patient's signs and symptoms, as well as the intrahepatic mass, resolved promptly after administration of amoxicillin. We consider that, in the present case, secondary syphilis caused the nephrotic syndrome and the intrahepatic mass, both of which have rarely been reported to date.

Keywords: Human immunodeficiency virus; Intrahepatic mass; Nephrotic syndrome; Secondary syphilis.

Publication types

Case Reports

MeSH terms

Adult
HIV Infections*
HIV-1
Humans
Liver Neoplasms*
Male
Nephrotic Syndrome*
Syphilis*

Supplementary concepts

Syphilis, secondary