In-situ vibrational optical rotatory dispersion of molecular organic crystals at high pressures

W Montgomery; Ph Lerch; M A Sephton

doi:10.1016/j.aca.2014.07.020

In-situ vibrational optical rotatory dispersion of molecular organic crystals at high pressures

Anal Chim Acta. 2014 Sep 9:842:51-6. doi: 10.1016/j.aca.2014.07.020. Epub 2014 Jul 19.

Authors

W Montgomery¹, Ph Lerch², M A Sephton³

Affiliations

¹ Department of Earth Science and Engineering, South Kensington Campus, Imperial College London, London SW7 2AZ, UK. Electronic address: [email protected].
² Swiss Light Source - Paul Scherrer Institute, CH 5232 Villigen-PSI, Switzerland.
³ Department of Earth Science and Engineering, South Kensington Campus, Imperial College London, London SW7 2AZ, UK.

PMID: 25127651
DOI: 10.1016/j.aca.2014.07.020

Abstract

Organic structures respond to pressure with a variety of mechanisms including degradation, intramolecular transformation and intermolecular bonding. The effects of pressure on chiral organic structures are of particular interest because of the potential steric controls on the fate of pressurized molecules. Despite representing a range of opportunities, the simultaneous study of high pressures on different forms of chiral structures is poorly explored. We have combined synchrotron-source vibrational optical rotatory dispersion, micro-Fourier transform infrared spectroscopy and the use of a diamond anvil cell to simultaneously monitor the effects of pressure on the two enantiomers of the simple amino acid, alanine.

Keywords: Alanine; Chirality; Diamond anvil cell; Fourier transform infrared spectroscopy; Vibrational optical rotatory dispersion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alanine / chemistry*
Crystallization
Equipment Design
Optical Rotatory Dispersion / instrumentation*
Pressure
Spectroscopy, Fourier Transform Infrared / instrumentation*
Stereoisomerism

Substances

Alanine