The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells

Mol Cell Endocrinol. 2014 Oct;396(1-2):26-36. doi: 10.1016/j.mce.2014.08.004. Epub 2014 Aug 12.

Abstract

The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypothyroidism, consequent to a reduced gland size and a deranged differentiation. These results demonstrate that Pax8 is also an essential player in controlling survival and differentiation of adult thyroid follicular cells.

Keywords: Cell survival; Pax8; Thyroid; Transcription factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Survival
  • Embryo, Mammalian
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Hypothyroidism / genetics*
  • Hypothyroidism / metabolism
  • Hypothyroidism / pathology
  • Hypothyroidism / physiopathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Organ Size
  • PAX8 Transcription Factor
  • Paired Box Transcription Factors / deficiency
  • Paired Box Transcription Factors / genetics*
  • Promoter Regions, Genetic
  • Signal Transduction
  • Thyroid Gland / cytology
  • Thyroid Gland / growth & development
  • Thyroid Gland / metabolism*
  • Thyroxine / genetics*
  • Thyroxine / metabolism

Substances

  • PAX8 Transcription Factor
  • Paired Box Transcription Factors
  • Pax8 protein, mouse
  • Thyroxine