Interferon-gamma-like immunoreactivity and T-cell marker expression in rat skeletal muscle fibres

I Nennesmo; T Olsson; A Ljungdahl; K Kristensson; P H Van der Meide

doi:10.1016/0006-8993(89)91374-7

Interferon-gamma-like immunoreactivity and T-cell marker expression in rat skeletal muscle fibres

Brain Res. 1989 Dec 18;504(2):306-10. doi: 10.1016/0006-8993(89)91374-7.

Authors

I Nennesmo¹, T Olsson, A Ljungdahl, K Kristensson, P H Van der Meide

Affiliation

¹ Department of Cellular and Neuropathology, Karolinska Institutet, Huddinge Hospital, Sweden.

PMID: 2513088
DOI: 10.1016/0006-8993(89)91374-7

Abstract

Interferon-gamma (IFN-gamma)-like-immunoreactivity was observed in subsets of rat skeletal muscle fibres with 3 different mouse monoclonal antibodies directed to rat IFN-gamma and a rabbit polyclonal anti-rat IFN-gamma-antibody. These strongly IFN-gamma-immunoreactive fibres also expressed antigen defining T-cells of the cytotoxic/suppressor phenotype (CD8) and major histocompatibility complex (MHC) class I antigen.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal
Antigens, Differentiation, T-Lymphocyte / metabolism*
Gene Expression Regulation*
Immunohistochemistry
Interferon-gamma / metabolism*
Male
Muscles / immunology*
Muscles / metabolism
Rats
Rats, Inbred Strains

Substances

Antibodies, Monoclonal
Antigens, Differentiation, T-Lymphocyte
Interferon-gamma