First report of spondylodiscitis due to vancomycin heteroresistant Staphylococcus capitis in immunocompetent host

Claudia Bianco; Fabio Arena; Barbara Rossetti; Giacinta Tordini; Lucia Migliorini; Paolo Galluzzi; Alfonso Cerase; Andrea De Luca; Gian Maria Rossolini; Francesca Montagnani

doi:10.1016/j.jiac.2014.04.004

First report of spondylodiscitis due to vancomycin heteroresistant Staphylococcus capitis in immunocompetent host

J Infect Chemother. 2014 Oct;20(10):639-42. doi: 10.1016/j.jiac.2014.04.004. Epub 2014 Aug 12.

Affiliations

¹ Department of Medical Biotechnologies, University of Siena, Siena, Italy.
² University Division of Infectious Diseases, Hospital Department of Specialized and Internal Medicine, Siena, Italy.
³ Unit of Neuroimaging and Neurointervention, Hospital Department of Neurological and Sensorineural Sciences, University Hospital of Siena, Siena, Italy.
⁴ Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy.
⁵ Department of Medical Biotechnologies, University of Siena, Siena, Italy; University Division of Infectious Diseases, Hospital Department of Specialized and Internal Medicine, Siena, Italy. Electronic address: [email protected].

PMID: 25131294
DOI: 10.1016/j.jiac.2014.04.004

Abstract

We report a successfully treated case of spondylodiscitis and bloodstream infection due to vancomycin heteroresistant Staphylococcus capitis, in an adult immunocompetent patient with multiple antibiotics intolerance. S. capitis is rarely involved in osteomyelitis and, to our knowledge, this is the first report of vancomycin heteroresistance phenomenon in an S. capitis strain causing spondylodiscitis.

Keywords: Spondylodiscitis; Staphylococcus capitis; Vancomycin heteroresistance.

Publication types

Case Reports

MeSH terms

Aged
Anti-Bacterial Agents / therapeutic use*
Bacteremia / drug therapy
Bacteremia / microbiology
Discitis / drug therapy
Discitis / microbiology*
Humans
Immunocompetence
Lumbar Vertebrae*
Male
Staphylococcal Infections / complications*
Staphylococcal Infections / drug therapy
Staphylococcus / drug effects*
Vancomycin Resistance*

Substances

Anti-Bacterial Agents