Abstract
(89)Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of (89)Zr-labelled (bio)conjugates with improved stability.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Line, Tumor
-
Chelating Agents / chemistry*
-
Coordination Complexes / chemical synthesis
-
Coordination Complexes / chemistry*
-
Coordination Complexes / metabolism
-
Crystallography, X-Ray
-
Deferoxamine / chemistry
-
Humans
-
Molecular Conformation
-
Molecular Probes / chemical synthesis
-
Molecular Probes / chemistry*
-
Molecular Probes / metabolism
-
Peptides / chemistry
-
Radiopharmaceuticals / chemical synthesis
-
Radiopharmaceuticals / chemistry
-
Radiopharmaceuticals / metabolism
-
Zirconium / chemistry*
Substances
-
Chelating Agents
-
Coordination Complexes
-
Molecular Probes
-
Peptides
-
Radiopharmaceuticals
-
Zirconium
-
Deferoxamine