A new piece in the kinetochore jigsaw puzzle

J Cell Biol. 2014 Aug 18;206(4):457-9. doi: 10.1083/jcb.201407048.

Abstract

In eukaryotic cell division, the kinetochore mediates chromosome attachment to spindle microtubules and acts as a scaffold for signaling pathways, ensuring the accuracy of chromosome segregation. The architecture of the kinetochore underlies its function in mitosis. In this issue, Hornung et al. (2014. J. Cell Biol. http://dx.doi.org/201403081) identify an unexpected linkage between the inner and outer regions of the kinetochore in budding yeast that suggests a new model for the construction of this interface.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Autoantigens / genetics*
  • Cell Cycle Proteins / metabolism*
  • Centromere Protein A
  • Chromosomal Proteins, Non-Histone / genetics*
  • Kinetochores / metabolism*
  • Microtubule-Associated Proteins / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Saccharomycetales / genetics*

Substances

  • Ame1 protein, S cerevisiae
  • Autoantigens
  • Cell Cycle Proteins
  • Centromere Protein A
  • Chromosomal Proteins, Non-Histone
  • Microtubule-Associated Proteins
  • Okp1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins