Thiol-activated gem-dithiols: a new class of controllable hydrogen sulfide donors

Org Lett. 2014 Sep 5;16(17):4536-9. doi: 10.1021/ol502088m. Epub 2014 Aug 20.

Abstract

A class of novel thiol-activated H2S donors has been developed on the basis of the gem-dithiol template. These donors release H2S in the presence of cysteine or GSH in aqueous solutions as well as in cellular environments.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cysteine / chemistry
  • Glutathione / chemistry
  • Hydrogen Sulfide / chemistry*
  • Molecular Structure
  • Sulfhydryl Compounds / chemistry*
  • Toluene / analogs & derivatives*
  • Toluene / chemistry

Substances

  • Sulfhydryl Compounds
  • Toluene
  • Glutathione
  • Cysteine
  • dithiol
  • Hydrogen Sulfide