Drug conjugation to cyclic peptide-polymer self-assembling nanotubes

Chemistry. 2014 Sep 26;20(40):12745-9. doi: 10.1002/chem.201403130. Epub 2014 Aug 21.

Abstract

We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500 nm) led to structures exhibiting high activity against cancer cells.

Keywords: drug conjugation; nanotubes; peptides; ruthenium; self-assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cymenes
  • Drug Carriers / chemistry*
  • Female
  • Humans
  • Models, Molecular
  • Nanotubes / chemistry*
  • Nanotubes / ultrastructure
  • Organometallic Compounds / administration & dosage*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology
  • Ovarian Neoplasms / drug therapy
  • Peptides, Cyclic / chemistry*
  • Polyhydroxyethyl Methacrylate / analogs & derivatives*
  • Polyhydroxyethyl Methacrylate / chemistry
  • Ruthenium / administration & dosage*
  • Ruthenium / chemistry
  • Ruthenium / pharmacology

Substances

  • Antineoplastic Agents
  • Cymenes
  • Drug Carriers
  • Organometallic Compounds
  • Peptides, Cyclic
  • dichloro(4-cymene)(1,3,5-triaza-7-phosphatricyclo(3.3.1.1)decane)ruthenium(II)
  • Polyhydroxyethyl Methacrylate
  • poly(2-hydroxyethyl acrylate)
  • Ruthenium