The intake of a hazelnut skin extract improves the plasma lipid profile and reduces the lithocholic/deoxycholic bile acid faecal ratio, a risk factor for colon cancer, in hamsters fed a high-fat diet

Food Chem. 2015 Jan 15:167:138-44. doi: 10.1016/j.foodchem.2014.06.072. Epub 2014 Jun 24.

Abstract

The effects on lipid and glucose metabolism of a hazelnut skin extract (FIBEROX™) administrated during 8 weeks (HFD-FBX8w group) or during the last 4 weeks of the study (HFD-FBX4w group) to Golden Syrian hamsters fed a high-fat diet (HFD) for 8 weeks were investigated. FIBEROX™ consumption reversed the increase in total and LDL plasma cholesterol induced by the HFD feeding in both HFD-FBX groups and decreased the circulating levels of free fatty acids and triglycerides in the HFD-FBX4w animals. The higher excretion of bile acids found in the faeces of both groups of hamsters fed the FIBEROX™ suggests that this mechanism is involved in the cholesterol-lowering effects of the extract. Furthermore, FIBEROX™ intake sharply decreased the lithocholic/deoxycholic bile acid faecal ratio, a risk factor for colon cancer, in both HFD-FBX groups. In conclusion, the consumption of FIBEROX™ improves different risk factors associated with cardiovascular disease and colon cancer.

Keywords: Bile acids; Blood cholesterol; Cardiovascular health; Colon metabolism; Hazelnut skin extract; Plasma lipid profile.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bile Acids and Salts / chemistry*
  • Colonic Neoplasms
  • Corylus / chemistry*
  • Cricetinae
  • Deoxycholic Acid / adverse effects*
  • Diet, High-Fat / adverse effects*
  • Lipids / blood*
  • Lithocholic Acid / adverse effects*
  • Male
  • Mesocricetus
  • Risk Factors

Substances

  • Bile Acids and Salts
  • Lipids
  • Deoxycholic Acid
  • Lithocholic Acid