Abstract
Two hundred rheumatoid patients were prospectively studied over a five-year period. One hundred and three received tiopronin (T) and 97 were treated with gold thiosulphate (GTS). At the end of the five-year period, similar percentages of patients dropped out because of lack of efficacy or because of major toxicities. Likewise, the percentages of patients still receiving the original drug in the two drug regimens at the 5th year of follow-up were 27.8% (GTS) vs. 25.2% (T), respectively.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adult
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Aged
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Arthritis, Rheumatoid / drug therapy*
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Drug Administration Schedule
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Drug Tolerance
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Female
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Follow-Up Studies
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Gold / therapeutic use*
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Gold Sodium Thiosulfate / administration & dosage
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Gold Sodium Thiosulfate / adverse effects
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Gold Sodium Thiosulfate / therapeutic use*
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Humans
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Injections, Intramuscular
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Male
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Middle Aged
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Prospective Studies
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Recurrence
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Severity of Illness Index
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Therapeutic Equivalency
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Tiopronin / administration & dosage
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Tiopronin / adverse effects
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Tiopronin / therapeutic use*
Substances
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Gold
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Tiopronin
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Gold Sodium Thiosulfate