The epigenetic landscape of Alzheimer's disease

Nat Neurosci. 2014 Sep;17(9):1138-40. doi: 10.1038/nn.3792.

Abstract

Two independent epigenome-wide association studies of Alzheimer’s disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer’s disease. These studies also suggest that epigenetic changes contribute more to Alzheimer’s disease than expected.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology*
  • Ankyrins / genetics*
  • Carrier Proteins / genetics*
  • Cerebral Cortex / physiology*
  • DNA Methylation / genetics*
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Nuclear Proteins / genetics*
  • Tumor Suppressor Proteins / genetics*

Substances

  • ANK1 protein, human
  • Adaptor Proteins, Signal Transducing
  • Ankyrins
  • BIN1 protein, human
  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • RHBDF2 protein, human
  • Tumor Suppressor Proteins