Abstract
The in vitro evaluation of antibacterial, antifungal and DNA-damaging properties of some 3-amino, 3-acylamino and 3-alkylaminoacylamino derivatives of 1,2-benzisothiazole is described. Compounds 1-8, 38 and 48 exhibited a selective antifungal activity while the other compounds did not show any significative activity. None of the compounds tested turned out to have any genotoxic properties.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents
-
Anti-Infective Agents / chemical synthesis*
-
Antifungal Agents / chemical synthesis*
-
Bacillus subtilis / drug effects
-
Bacillus subtilis / genetics
-
Bacteria / drug effects
-
Chemical Phenomena
-
Chemistry
-
DNA Damage*
-
Fungi / drug effects
-
Microbial Sensitivity Tests
-
Mutagenicity Tests
-
Mutagens*
-
Structure-Activity Relationship
-
Thiazoles / chemical synthesis*
-
Thiazoles / pharmacology
Substances
-
Anti-Bacterial Agents
-
Anti-Infective Agents
-
Antifungal Agents
-
Mutagens
-
Thiazoles